Study of brain development

The cortical folding process is studied from antenatal imaging in order to infer models of the sulcus interruptions
A: The central sulcus is made up of two sketches, which we call sulcal roots.
B: Sometimes, the two roots do not merge together leading to an interruption pattern.
C: Most of the time, clues about the sulcal roots can be found in the depth of the adult sulci.

Collaboration between:

Service Hospitalier Frédéric joliot, CEA, and ERITM Psychiatrie et Imagerie, INSERM Orsay
Service de Neurochirurgie Fonctionnelle et Stéréotaxique, La Timone, Marseille
Hôpital des enfants malades, Necker, Paris

J. Régis, J.-F. Mangin, V. Frouin, F. Sastre, L. C. Peragut, and Y. Samson,
Cerebral cortex generic model for cortical localization and preoperative multimodal integration in epilepsy surgery, Stereotactic and Functional Neurosurgery , vol 65, pp. 72-80, 1995

A. Cachia, J.-F. Mangin, D. Rivière, F. Kherif, N. Boddaert, A. Andrade, D. Papadopoulos-Orfanos, J-B. Poline, I. Bloch, M. Zilbovicius, P. Sonigo, F. Brunelle, and J. Régis.
A Primal Sketch of the Cortex Mean Curvature: a Morphogenesis Based Approach to Study the Variability of the Folding Patterns IEEE Transactions on Medical Imaging, in press, 2003.